Systems biology is largely tributary to genomics and other “omic” disciplines that generate vast amounts of structural data. “Omics”, however, lack a theoretical framework that would allow using these data sets as such (rather than just tiny bits that are extracted by advanced data-mining techniques) to build explanatory models that help understand physiological processes. Systems biology provides such a framework by adding a dynamic dimension to merely structural “omics”. It makes use of bottom-up and top-down models. The former are based (...) on data about systems components, the latter on systems-level data. We trace back both modeling strategies (which are often used to delineate two branches of the field) to the modeling of metabolic and signaling pathways in the bottom-up case, and to biological cybernetics and systems theory in the top-down case. We then argue that three roots of systems biology must be discerned to account adequately for the structure of the field: pathway modeling, biological cybernetics, and “omics”. We regard systems biology as merging modeling strategies (supplemented by new mathematical procedures) from data-poor fields with data supply from a field that is quite deficient in explanatory modeling. After characterizing the structure of the field, we address some epistemological and ontological issues regarding concepts on which the top-down approach relies and that seem to us to require clarification. This includes the consequences of identifying modules in large networks without relying on functional considerations, the question of the “holism” of systems biology, and the epistemic value of the “systeome” project that aspires to become the cutting edge of the field. (shrink)

Visual conscious perception could be grounded in a nonconscious sensorimotor domain. Although invisible, information can be processed up to the level of response activation. Moreover, these nonconscious processes are modified by actual intentions. This notion bridges a gap in the theoretical framework of O'Regan & Noë.

With this issue of the Journal of Research Practice, we initiate a conceptual framework for thinking and writing about research, defining areas of editorial focus, and indexing work published in the journal. The framework takes the form of a concept hierarchy that offers index terms at three interrelated levels: (1) focus areas for reflection on research practice within which the journal aims to achieve excellence and strengthen its profile and visibility, (2) subject areas relevant to research practice that the journal (...) aims to cover and in terms of which it defines its focus areas, and (3) keywords for capturing the content of research work done in these subject areas or for reflecting and writing about it. Focus areas are characterized by assigned subject areas; subject areas are characterized by assigned keywords. The concept hierarchy is part of a more comprehensive initiative to strengthen the journal's profile and visibility, an initiative that will also include a restructuring of the editorial team and new roles for the journal's dedicated reviewers and active readers. The article introduces an initial version of the concept hierarchy, explains its intended use and further development, and situates it in the larger effort of which it is a part. (shrink)

This Festschrift in honour of Werner G. Jeanrond, currently Master of St Benet's Hall, University of Oxford, UK, investigates the challenge of alterity for Christianity, exploring and elaborating on this core concern in Jeanrond's hermeneutical theology. Blurring disciplinary boundaries, more than thirty of Jeanrond's colleagues and companions from ten countries track the dynamics of difference driven by the encounter with the self as other, the other as other, and God as the radical other. Who is my other? What do (...) I encounter when I encounter my other? And what responses and responsibilities does the encounter with my other evoke? Grappling with questions like these, the contributions to this compilation analyse alterity in the Bible, alterity in philosophy, alterity in theology, alterity in interreligious dialogues, and the radical alterity of God. Tying in with Jeanrond's explorations of the many faces and facets of the other, this Festschrift ultimately aims to advocate openness to the other as a necessity for both religion and reflections on religion. (shrink)

This editorial article reports on the progress that the Journal of Research Practice (JRP) has achieved in its ongoing development since November 2011, when a number of editorial initiatives were announced. Several new initiatives are also proposed. In addition, there are some current announcements, including a number of recent awards, distinctions, and nominations.

Review:Die Kunst vernetzt zu denken: Ideen und Werkzeuge für einen neuen Umgang mit Komplexität [The Art of Network Thinking: Ideas and Tools for a New Way of Dealing with Complexity.] Book by Frederic Vester . Published by Deutsche Verlags-Anstalt, Stuttgart, Germany, 1999, , 315 pp., ISBN 3-421-05308-1, EUR 22.80. , Munich, Germany, 2002, 348 pp, ISBN 3-423-33077-5, EUR 12.50).

With this article we introduce a new article category in the journal, as announced in this issue's editorial--Viewpoints & Discussion. Articles under this category are intended to provide authentic and qualified opinions on topics relevant to the journal. These articles and follow-up discussions will pass through an accelerated, mainly editorial, review process. We invite readers to respond to such articles by sharing their personal thoughts and experiences, as well as to initiate new discussions. We hope these contributions will make the (...) journal a site for lively discussions on research practice. For this first "Viewpoint" we have selected a topic that should be of interest to many readers: What key research competencies will researchers and professionals need to have in the future? To introduce the topic, we look into a recent comparative study on this question that compares the situation in eight research-intensive countries. Reports on the study are available for free download, which can serve as a basis for discussion. In keeping with the idea of "Viewpoints & Discussion," no claim to offering a systematic and scholarly account of the topic is intended; the only aim is to throw a spotlight on a theme of current interest and to suggest a few pertinent conjectures and questions for discussion. (shrink)

We all know that ships are safest in the harbor; but alas, that is not what ships are built for. They are destined to leave the harbor and to confront the challenges that are waiting beyond the harbor mole. A similar challenge confronts the practice of research. Research at work cannot play it safe and stay in whatever theoretical and methodological harbors in which it may have found shelter in the past. Still less can it examine and maintain its foundations (...) in the dry dock. Research is more like a ship that must be repaired on the open sea. Yet foundationalist ideas persist in the practice of research. Counter to what is often assumed, today’s dominating model for research--the fallibilist model of critical rationalism--has not really overcome the empirical foundationalism of earlier, positivist research practices. This paper analyses two major foundationalist traps that are currently in the upswing and work against reflective research practice. (shrink)

Review of "The Timeless Way of Building." Book by Christopher Alexander.

Following a detailed review of the accomplishments and aspirations of the Journal of Research Practice, we have undertaken a restructuring of the editorial board, with inputs from people associated with this journal. In designing the new structure, we have taken into account the need for building the journal’s profile in the six focus areas recently clarified: (1) Research Applications, (2) Research Spaces, (3) Research Education, (4) Research Experiences, (5) Research Philosophy, and (6) Research on Research. Focus Editors will ensure that (...) the journal remains well engaged with the developments in these focus areas. The new structure allows us to involve all contributors to the journal in playing a role to enhance the journal’s relevance to researchers and reflective professionals. This restructuring exercise has presented us with an opportunity to build on the strengths of the journal and address areas of concern so as to strengthen the journal’s quality, relevance, and impact. A review of different notions of impact has led us to a set of proposed measures for enhancing the relevance and utilisation of the journal in future. (shrink)

Karl Jaspers zählt zu den bedeutendsten Philosophen des 20. Jahrhunderts. Obwohl es bereits eine international etablierte Jaspersforschung gibt, haben die meisten seiner Werke jedoch noch keinen angemessenen Eingang in die historische und systematische Lehre der Philosophie gefunden. Diese Aufsatzsammlung gibt erstmals einen Einblick in die wichtigsten Begriffe seines philosophischen Denkens. Zu diesen Begriffen gehören Begriffe wie Grenzsituation, Freiheit, Menschenbild, Kommunikation, Philosophischer Glaube, Chiffre, Böses, Wahrheit, Vernunft, Gehäuse, Wissenschaft, Logik, Sprachphilosophie, Psychopathologie, Psychologie der Weltanschauung, Ethik, Einsamkeit, Erziehung, Politik, Universität, Achsenzeit, Philosophia (...) perennis und interkulturelle Philosophie. Einige dieser Begriffe wurden von Jaspers geprägt und gingen dauerhaft als neue Begriffe in die Philosophie, die Psychologie und die Psychopathologie ein. Die anderen Begriffe knüpfen zwar dem Wortlaut nach an die klassische Tradition der europäischen Philosophie an, wurden von Jaspers jedoch im Sinne einer Weltphilosophie umgestaltet und erweitert. Dieser Sammelband ist nicht nur ein einführendes Kompendium für Studierende der Philosophie, der verschiedenen Theologien der Weltreligionen sowie der Sozial- und Kulturwissenschaften. Er kann auch philosophisch Interessierten den Zugang zur Philosophie von Jaspers erleichtern. (shrink)

In einer kühnen Metapher haben einst Hieronymus, Erasmus und Luther die Heilige Schrift als ein Labyrinth bezeichnet, das die Leser bei fortgesetztem Lesen in eine sich sogar steigernde Verwirrung stürze. Beinah im selben Atemzug wird eben dieselbe Heilige Schrift von eben denselben Autoren als der einzige Faden gepriesen, der die Leser aus dem Labyrinth ihres Lebens herausführe. Eines und dasselbe als Labyrinth und als Faden: Diese Figur ist paradigmatisch. Im Labyrinth der Ethik geht es nicht anders zu. Nur wer sich (...) ihm überläßt, findet aus ihm heraus. 24 Beiträge von namhaften Theologen und Theologinnen zur Theologischen Ethik finden sich in den fünf Abschnitten des vorliegenden Buches, das nacheinander "Biblische Grundlagen", "Theologische Systematik", "Ethische Modelle", "Ethische Leitbegriffe" und "Ethik und die Religionen" behandelt: Hans-Dieter Bastian: Zwischen Glauben und Handeln: Bibel-Lesen - Werner H. Schmidt: Glaube und Handeln. Aspekte des Alten Testaments - Wolfgang Schrage: Der 1. Korintherbrief als Paradigma paulinischer Ethik - Michael Wolter: Der Kompromiß bei Paulus - Jörg Haustein: Beobachtungen zum Schriftverständnis ökumenischer Dokumente - Gerhard Sauter: "Schrifttreue" in ethischer Urteilsbildung Günter Bader: Handeln im Namen Gottes - Erich Gräßer: Die ersten und die letzten Dinge. Bemerkungen zur theologischen und ethischen Schöpfungswahrnehmung - Marcin Hintz: Glaube, Tradition, Vernunft: Auf den Spuren theologischer Urteilsbildung im polnischen Protestantismus - Rolf Schäfer: Christliche Glaubens- und Sittenlehre bei Schleiermacher - Karl-Wilhelm Dahm: Herausforderungen für Selbstverständnis und Rolle des protestantischen Pfarrers im Zuge des Modernisierungsprozesses Traugott Jähnichen: Sozialethik auf dem Weg der Ausbildung von Bereichsethiken - Historische Traditionen und perspektivische Herausforderungen - Ulrich Eibach: Christengemeinde und christliches Leben und Handeln in der pluralistischen Gesellschaft - Ludger Honnefelder: Gesundheit unser "höchstes Gut"? Wertentscheidungen im Rahmen der Ressourcenallokation im Gesundheitswesen - Jörg Hübner: Kollektives Handeln im Zeitalter der Globalisierung. Perspektiven für eine zukünftige politische Ethik - Gottfried Hütter: Menschenwürde und Menschenrechte für Tiere? - Tobias Schlingensiepen: Adam, wo bist du? Die Entkontextualisierung menschlichen Lebens als Problem u. Herausforderung evangelischer Ethik Edgar Thaidigsmann: "Ehrfurcht vor dem Leben". Das Problem der Begründung einer Ethik der Verantwortung für das Lebendige bei Albert Schweitzer und Hans Jonas - Konrad Stock: Laster - der "vielnamige Frevel". Eine theologische Erinnerung an ein vergessenes Problem - Ulrich H. J. Körtner: Bildung und Wertebewußtsein. Anmerkungen zum Wertbegriff in der aktuellen Bildungsdiskussion - Hans G. Ulrich: Güter oder Werte? Zur Aufgabe der Theoriebildung in der evangelischen Sozialethik - Hartmut Kreß: Toleranz als Verpflichtung protestantischer Ethik Hans Waldenfels: Unterwegs zu einer interreligiösen Theologie - Sung-Hee Lee-Linke: Interreligiöse Ethik. Ein Modell für die Zukunft? (shrink)

Gutes und Guter, Leben, Leib, Tugend - in diesem Band werden die Vortrage der ersten vier Symposien der Mainz Moral Meetings aus den Jahren 2009-2011 zu diesen Themen zusammengefasst. Ein interdisziplinarer Zugang durch Bibelwissenschaft, Judaistik, Altphilologie, Philosophie, Patristik, Systematische Theologie und weiteren Disziplinen eroffnet einen Blick auf die ethischen Normen des fruhen Christentums. Die Autoren der Beitrage fragen nach den Moglichkeiten von Norm und Normbegrundung einer fruhchristlichen Ethik in ausgewahlten Bereichen sowohl im Kontext antiker Philosophie als auch in gegenwartiger Verantwortung. (...) Mit Beitragen von: Jochen Althoff, Frederick D. Aquino, Wilhelm Blumer, Maximilian Forschner, Christian Hengstermann, Christoph Horn, Friedrich W. Horn, David Horrell, Manfred Lang, Sebastian Moll, Maren Niehoff, Jorg Roder, Eckart David Schmidt, Nikolaus Schneider, Lorenzo Scornaienchi, Notger Slenczka, Mira Stare, Gerd Theissen, Ulrich Volp, Jan G. van der Watt, Werner Zager, Ruben Zimmermann. (shrink)

Nicht nur mit Engelszungen: Beiträge zur semitischen Dialektologie—Festschrift für Werner Arnold zum 60. Geburtstag. Edited by Renaud Kuty; Ulrich Seeger; and Shabo Talay. Wiesbaden: Harrassowitz Verlag, 2013. Pp. xx + 412. €118.

Many scholars suggest that one of the main differences between Xenophon’s and Plato’s portrayals of Socrates is in their emphases on the self-control the self-knowledge respectively. The aim of the paper is to examine the role the self-knowledge plays in Xenophon’s Memorabilia. In its first part Xenophon’s conception of the self-knowledge is analysed. Then it tries to answer the question whether the self-knowledge requires any preconditions. The last part is focused on the possible obstacles precluding the self-knowledge.

Der Psychiater und Philosoph Karl Jaspers hinterließ eine große fachliche und persönliche Korrespondenz, die historisch vom Untergang des Kaiserreichs bis zur Etablierung der Bundesrepublik reicht. Diese kritische und kommentierte Edition vermittelt ein umfassendes Bild dieses Denkers. Briefpartner dieses Bandes:Gustav Bally, Kurt Beringer, Ludwig Binswanger, Eugen Bleuler, Max Born, Albert Fraenkel, Viktor E. Frankl, Robert Gaupp, Wolfgang Gentner, Hans Walter Gruhle, Willy Hellpach, Jakob Klaesi, Ludwig Klages, Kurt Kolle, Ernst Kretschmer, Arthur Kronfeld, Willhelm Mayer-Gross, Alexander Mitscherlich, Rudolf Nissen, Franz Nissl, Curt (...) Oehme, Wolfgang Pauli, Oskar Pfister, Hans Prinzhorn, Werner Scheid, Gerhard Schmidt, Kurt Schneider, Johannes Heinrich Schultz, Albert Schweitzer, Hugo Spatz, Georg Stertz, Hans Jörg Weitbrecht, Carl Friedrich v. Weizsäcker, Viktor v. Weizsäcker, Albrecht Wetzel, Karl Wilmanns, Richard Woltereck, Jürg Zutt. (shrink)

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

The question is, of whether alongside a theme and method concentrated philosophy teaching it would be sensisible for young people to have a teaching form where great philosophers themselves are the centre of interest and are presented as personalities engaged in philosophical research. As an illustration the philosophers Plato, René Descartes, John Locke and Immanuel Kant, who essentially laid down the foundations of modern scientific thinking, would be presented in relationship to teaching practice. This train of thought can be extended (...) without exception for all nations and all forms of culture so long as the conditions of peaceableness and civilizing productivity are met with. Exemplary biographies could play a large role for young people with regard to their psychological development. (shrink)